On average, someone in the U.S. has a stroke every 40 seconds. Acute ischemic stroke remains one of the leading causes of death and disability in the U.S. and around the world. The American Heart Association (AHA) estimates that in 2016 there were 5.5 million deaths attributable to cerebrovascular disease worldwide — 2.7 million of those deaths were from ischemic stroke. May is National Stroke Awareness Month and provides the opportunity to remember patients who are survivors of this dreaded disease and highlight the physicians and researchers at the forefront of progress to improve care and outcomes in stroke.
Over the last five years, there have been significant advancements in the treatment of acute ischemic stroke secondary to large vessel occlusion (LVO). LVO is an especially disabling form of ischemic stroke because a large territory of brain tissue and function is typically affected. Five landmark clinical trials published in the New England Journal of Medicine in 2015 and 2016 (MR CLEAN, ESCAPE, EXTEND IA, SWIFT PRIME, and REVASCAT) all demonstrated overwhelming benefit for mechanical thrombectomy for LVO. In summary, the studies suggested that only three patients need to be treated with thrombectomy to improve the functional outcome of one patient (number needed to treat (NNT) of 3). This makes mechanical thrombectomy one of the most effective treatments not only in stroke but in all of medicine. The AHA quickly amended its guidelines to recommend thrombectomy for ischemic stroke patients. However, the recommendation was reserved for a select number of indications, including:
- occlusions of the internal carotid artery (ICA) and proximal middle cerebral artery (MCA) segments of the cerebrovascular tree;
- those who had received intravenous (IV) tissue plasminogen activator (TPA);
- those with good baseline functional status; and
- those being treated within 6 hours of symptom onset.
These were significant steps in the right direction; however, there are still many patients who fall outside these indications which might benefit from mechanical thrombectomy.
Since then, indications for thrombectomy have expanded. In 2019, two additional trials were published in the New England Journal of Medicine (DAWN and DEFUSE3) that demonstrated similar positive outcomes in select patients being treated up to 24 hours from symptom onset. Research to establish the role of thrombectomy in several other groups of patients is ongoing, including studies involving:
- pediatric patients;

- the elderly;
- more distal occlusions in the cerebrovascular tree;
- posterior circulation occlusions;
- patients with mild stroke symptoms despite evidence of large vessel occlusion; and
- other conditions.
There remains much to learn about this powerful treatment, and hopefully, the indications for mechanical thrombectomy will continue to expand.
Another active area of research is the improvement in stroke care delivery. Researchers are developing new systems to administer care for stroke patients as quickly and efficiently as possible. Emergency medical services (EMS) and stroke triage systems are being redesigned, often across hospital systems. In some cases, the stroke care team is coming to the patient rather than the patient to the team. In other cases, patients with a high likelihood of LVO bypass closer primary stroke centers and are brought to comprehensive stroke centers for thrombectomy. Artificial intelligence-based tools help identify and select patients earlier for these advanced therapies. New diagnostic tools are being developed that can be utilized by EMS providers in the field. Robotic mechanical thrombectomy and the potential of tele-mechanical thrombectomy are exciting advances on the horizon.
Finally, stroke, large vessel occlusions and mechanical thrombectomy have become an area of interest amid the COVID-19 pandemic. Evidence is emerging from epicenters of the crisis — like New York City — that patients, whether afflicted with COVID-19 or not, are seeking medical attention later in their stroke course due to fears regarding COVID-19. We expect many studies to be published in the ensuing months evaluating stroke and mechanical thrombectomy in COVID-19 patients. We are excited about what the future holds in cutting edge research to bring the best available care to stroke patients everywhere.
Editor’s note: We hope that you will share what you learn from our posts. We invite you to be part of the conversation on Twitter by following and using the hashtag #COVID19.
Justin R. Mascitelli, MD
University of Texas Health Science Center at San Antonio
St. Luke’s Baptist Hospital
San Antonio, Texas
Clemens M. Schirmer, MD, PhD, FAANS, FAHA
Chair, AANS/CNS Communications and Public Relations Committee
Geisinger
Wilkes Barre, PA

Other Navy Reserve doctors and nurses are embedded into the New York City public city hospitals that have been decimated with COVID-19. Navy Reserve doctors and nurses are joining their civilian counterparts in treating COVID-19 patients in hospitals where they are most needed. Many are acting in new and expanded roles due to the dramatically increased ICU needs. The shortage does not call for additional neurosurgeons to perform neurosurgery but for additional coverage in overflowing ICUs. These are very sick patients, and neurosurgeons have a tremendous possibility to do some good within this structure. As our medical critical care colleagues take a pounding, neurosurgeons are very comfortable in the ICU, in treating critical patients, in dealing with mortality and in leading large health care teams to make pragmatic, direct and impactful decisions. Indeed, the
It goes without saying that service in the Navy Reserve rests upon the service of others. Colleagues back home have taken additional emergency call, increased their workload and served the local community in similar ways. Even more so, spouses have to work overtime at home, especially those with small children and those juggling their own virtual careers. Multiple people have come together in numerous ways to serve the people of New York City. And, the welcome in New York City has been one of deep gratitude both inside and outside the hospital.
Initially, physical classes were canceled until late March, by which time any students who had traveled to a COVID-19 hotspot would have completed a 14-day quarantine. The plan was to resume regular classes and clinical experiences following this disruption. However, it became clear within a matter of weeks that this would be impossible. For the safety of students, faculty and patients, it was eventually decided that all physical classes and clinical experiences would be canceled for the foreseeable future. Students at all levels were placed in an uncertain position as it became increasingly clear that in-person learning would not be possible for the remainder of the year. This uncertainty fostered fear and anxiety among students — many of whom were also dealing with the stress regarding their safety and that of friends and family.
Stephen Susa
Life in neurosurgery changed in step with the sweeping changes across the medical community, necessitated by potential supply shortages and increased patient volume. As social distancing took effect, the coveted morning sign-out — the bedrock of day-to-day functioning of a busy neurosurgery service — was transitioned to video conferencing. Next was the cancellation of all elective cases, then semi-urgent cases, and eventually, in some hospitals, emergency cases could only be performed after chair/faculty committee approval. Clinic visits were canceled if deemed non-urgent or conducted as telemedicine visits to provide care while limiting disease spread. To protect residents from unnecessary exposure and maintain a reserve, call schedules were changed to limit the number of residents seeing consults at one time or available for cases. As these changes were implemented, unprecedented collaboration, flexibility and ingenuity was prevalent as everyone did their part to ensure care remained as safe and effective as possible.
Redi Rahmani, MD
Nathaniel R. Ellens, MD
Tyler M. Schmidt, DO
Then, for one-week, cases of COVID-19 filled the MICU. Shortly after that, our neurosurgical step-down — followed by the neurosurgical ICU — were rapidly converted into negative pressure rooms for COVID-19 patients. That same week, our hospital system placed a hold on all elective, non-emergent surgeries. By Friday, March 20, at a time when there were 
The CNS Town Hall Xperience provides an informal and interactive format, where experts discuss their experiences and answer questions from members. Members can submit topics and questions in advance of the session, as well as during the session. Sessions are facilitated by preeminent faculty.
John Ratliff, MD, FAANS, FACS
Before becoming a neurosurgery resident at
Myron L. Rolle, MD, MSc

